Chronic Inflammation

What is Inflammation?

Inflammation is the body’s normal response to protect tissues from infection, injury, or disease. The inflammatory response is a complex process with several characteristic features that include the activation of monocytes, granulocytes, and lymphocytes and the release and activation of inflammatory mediators, the complement system, and humoral mediators.

The inflammatory process begins with a stimulus that causes the release of prostaglandins from cells. Stimuli such as lipopolysaccharides (membrane component of bacteria) can induce inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). COX-2 acts by producing prostaglandin E2 (PGE2). In turn, PGE2 acts inside the cell to produce various types and quantities of cytokines, which are pro-inflammatory agents that complete the process by bringing active leukocytes to the injury site. These cells destroy any infective or injurious agent, and remove cellular debris from damaged tissue. Most of the time, inflammation is a lifesaver that enables our bodies to fend off various disease-causing bacteria, viruses and parasites. In acute situations, the process subsides quickly and healing begins.

What Causes Inflammation to Continue?

There are many reasons why the inflammatory process may persist and become chronic. Sometimes the problem is a genetic predisposition; other times something like smoking, high fat diet, or high blood pressure keeps the process going. When inflammation becomes chronic rather than short-term, it can seriously damage viable host tissue. Accumulating evidence suggests that chronic inflammation may be a root cause of a wide range of progressive diseases.

How Does Inflammation Contribute to Disease Development?

Supported by extensive research and clinical evidence, chronic inflammation promotes disease development and progression by:
Impairing endothelial function and vascular lining;
Increasing platelet activation and clotting;
Depleting intrinsic antioxidants;
Generating free radicals and amplifying oxidative stress;
Delaying wound healing and tissue regeneration;
Promoting cell aging and premature cell death;
Suppressing or amplifying immune responses.
What Diseases Are Linked With Chronic Inflammation?

Chronic inflammation promotes progression of atherosclerosis and destabilizes fatty plaque in coronary and carotid arteries, leading to heart attack and stroke. Chronic inflammation also destroys nerve cells in the brains of Alzheimer’s victims and facilitates the development and progression of cancer. It has been widely accepted that chronic inflammation may be the engine that drives many of the most feared illnesses of middle and old age (Diagram).

Chronic Inflammation-related Progressive & Degenerative Diseases

AIS: Amyotrophic Lateral Sclerosis
CKD: Chronic Kidney Disease
IBD: Inflammatory Bowel Disease
COPD: Chronic Obstructive Pulmonary Disease
RA: Rheumatoid Arthritis
CIDP: Chronic Inflammatory Demyelinating Polyneuropathy
CICTD: Chronic Inflammatory Connective Tissue Diseases
DDD: Degenerative Disc Disease

How To Treat Chronic Inflammation And Inflammation-related Conditions?

For decades, non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat chronic inflammation and inflammation-associated conditions. At high dose, NSAIDs reduce inflammation by inhibiting the activity of cyclooxygenease-1 (COX-1) and COX-2. Inhibition of COX-1, the enzyme that protects the stomach lining, causes stomach ulcers in 25% of NSAIDs users. Each year, half million Americans develop complications from NSAIDs, with an estimated 100,000 patients requiring hospitalization and more than 16,000 deaths.

The newer NSAIDs, selective COX-2 inhibitors, have showed little progress in reducing gastrointestinal adverse drug reactions. Moreover, society was dramatically shaken by the withdrawal from the marketplace of multibillion-dollar COX-2 inhibitor Vioxx due to increased risk of heart attack and stroke. Since then, the FDA has required strong warning labels on all NSAIDs.

Alternative Anti-inflammatory Products

Because oxidative stress causes inflammation, antioxidants have been advertised as anti-inflammatory agents. Although some studies have suggested that antioxidant supplements have health benefits, other large clinical trials did not detect any benefit from the formulations tested. Studies also raised concerns that the excess supplementation may occasionally be harmful. Facing the increased popularity of antioxidant supplements, the American Heart Association has issued the following statement: “Antioxidant supplements have no effect on cardiovascular risk. There is no good reason, at this point, to spend your money on antioxidant supplements.”

Many botanical medicinal herbs, used in Ayurvedic medicine and in traditional Chinese medicine for thousands of years, have anti-inflammatory properties. They are the core ingredients in FlameEz products. Using validated natural ingredients in a proprietary combination, FlameEz remedies are set to deliver optimum levels of performance in safety and potency.


I have a tattoo on the back of my neck, it is a fairy sitting on a morning glory, within her wings are the sun signs of Aquarius, that would be me, Scorpion, that would be my son, and Picese, that would be my daughter that passed away when she was 15 months old. She is a beautiful fairy with red hair and a hazy blue shift on. Under the morning glory she is sitting on it says “Believe”, I have many items that say “Believe” on them, Believe in what? Whatever makes you happy, whatever gives you peace, whatever makes it through another day. I firmly believe that we are not here to simply live life, nor do I believe that life ends when you die, it just changes. I believe that if you can think good things, release negative energy and bitterness that you can do anything you want to do. I BELIEVE!

Ready or not…

We have just returned from sufficiently stuffing ourselves with Mexican food. It’ll be noodles from here on out, at least starting Friday when we arrive in Beijing. I have mixed emotions, excitement, anticipation and fear. I am not sure what order as they seem to come in different waves. I need to just slow down and enjoy the next two weeks, just take them as they come. Like JE says, i have no control over these things so why worry about them. Tait is in need of some Mommy cuddling so i best be doing my job.

3 days

We are three days to take off. In less than a week we will be parents again and Tait will be a big brother. In a very positive way, our lives will be changing. It is a nice feeling. Yesterday we went to a “waiting families event.” This is a gathering of people who are in some phase of the adoption process with our agency. I can remember going to our first meeting and looking at those people who were about to leave to get their babies and now we are one of those people! We are almost packed and only a little over our goal. If i were not taking snacks we would probably be a little lighter! (I assume JE will make me leave some behind. It is either food or baby items.) Trying to do last minute tasks that need to be done. I slept well last night. I am sure these next few will be restless.

Mirena Lawyers

Mirena attorneys may be all that stand between you and financial ruin. If you received a birth control Mirena intrauterine device (IUD) or intrauterine device and suffered serious injury, you face medical costs, lost wages and pain and suffering. Those losses are the responsibility of the negligent maker of a IUD birth control.

Side Effects and Complications

Mirena lawyers from our firm have the skill, knowledge and experience to press your case in the legal arena with a lawsuit. Such a Mirena side effects lawsuit can target Bayer, which manufactured the defective medical device and is legally responsible for complications and injuries.

Mirena injuries can include infertility, miscarriage, weight gain and serious infections. The side effect lawsuit also can include perforation of the uterus and the intestine, as well as abscesses, adhesions and expulsion of this IUD. They also can include migration of the IUD to other parts of the body beyond the uterus.

Additional negative effects which can be the basis of Mirena lawsuits include pelvic pain, headaches, irregular spotting or bleeding, vaginitis, breast tenderness, painful menstruation, acne, ovarian cysts, amenorrhea and pelvic inflammatory disease or PID, which can be particularly damaging.

Some of these unwanted effects even can be life-threatening. Clearly, they can be the basis of a side effect lawsuit filed by our law firm.

Legal Fees

Will you have to pay legal fees to our lawyers? In truth, you will not. Our birth control Mirena lawyers work under what’s known as a contingency fee agreement, which signifies that they aren’t paid unless your case prevails, and then from the settlement amount.

Free Legal Consultation

How can you acquire help? You can simply notify our law firm, for starters. Then you’ll receive free legal advice in a free legal consultation, and you can speak with a female legal representative of our law firm if you wish.

If you then choose our law firm to represent you, we can provide you with one of the lawyer to file a Mirena malpractice lawsuit on your behalf. And such lawsuit is unlikely to go to trial, since most such injury lawsuits don’t go to trial but instead are resolved by negotiations reaching an out of court settlement.

Do the law firm’s sound like a good fit for you? If so, please call us or write us today about your Mirena class action lawyers by using this website’s online case review form.

We’ll promptly respond with support for your case, and soon perhaps you can acquire legal representation from among the experienced Mirena IUD lawyer at our firm.

Achieve your Weight Loss Goals at Berg Health and Wellness Center

There are very many people in various parts of the world who are doing all they can to lose excessive body weight. Some of these are even engaging in risky practices which can cause a permanent harm to their health. Berg Health and Wellness Center is a renowned place that has helped many people in achieving their desired body weight through healthy means. This facility is known for its friendly and understanding practitioners who handle patients in a very humane way. Berg Health and Wellness Center uses natural and nutritional methods to help individuals lose excessive body weight. According to this center, you do not lose weight through hard exercising. This is contrary to the belief of many people that the harder you exercise, the more the weight you lose.

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